How the body's internal clock affects metabolism and gene regulation as we age
Official title: Circadian Pathways Linking Metabolic Homeostasis and Gene Regulation During Aging
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10901043 · Data updated 2026-11-12
This study is looking at how changes in our body's natural clock can affect the health of older adults, especially when it comes to energy and metabolism, and it hopes to find ways to help keep people healthy as they age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $386,900 |
| NIH project number | 1R56AG082808-01 |
| Project ID | NIH-10901043 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 21 and above who may be experiencing metabolic issues related to aging.
✕Less likely to help
Patients who are younger than 21 or do not have age-related metabolic concerns may not benefit from this research.
What this research studies
This research investigates the relationship between circadian rhythms and metabolic health in older adults. It focuses on how disruptions in the body's internal clock can lead to metabolic decline and age-related health issues. By studying specific receptors involved in circadian regulation, the research aims to understand their role in maintaining energy balance and overall health during aging. The approach includes both genetic studies in mice and potential applications for human health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving metabolic health and quality of life in older adults.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in metabolism, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Chen, Zheng — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Chen, Zheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.