How the body's internal clock affects heart health through a key enzyme.
Circadian regulation of NAMPT in the heart
This study is looking at how a key enzyme called NAMPT helps control a important molecule for heart health throughout the day, and it aims to find out how this affects heart function and recovery from injury, which could lead to new treatments for heart problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10688124 on NIH RePORTER |
What this research studies
This research investigates the role of a crucial enzyme, NAMPT, in regulating levels of NAD+, a vital molecule for heart health, throughout the day. By understanding how NAMPT's activity changes with the circadian rhythm, the study aims to uncover its impact on heart metabolism and resistance to injury. The researchers will use advanced techniques in both human heart cells derived from stem cells and mouse models to explore these mechanisms. This could lead to new insights into how timing affects heart function and potential therapies for cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular diseases or those at risk for heart-related conditions.
Not a fit: Patients with non-cardiovascular conditions or those not affected by metabolic issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that optimize heart health by aligning therapies with the body's natural rhythms.
How similar studies have performed: Previous research has shown promising results in understanding circadian rhythms in other biological processes, suggesting potential for success in this novel approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Zhang, Lilei — Baylor College of Medicine
- Study coordinator: Zhang, Lilei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.