How the body's internal clock affects enteric virus infections
Circadian control of enteric virus infection
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11013404
This study is looking at how our body's natural daily rhythms might affect how well we fight off certain viruses, like coxsackievirus B3, and it aims to find better ways to treat these infections by understanding the best timing for treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11013404 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between circadian rhythms, which are the body's natural 24-hour cycles, and enteric virus infections, specifically focusing on how the timing of infection influences viral replication. By studying the effects of these rhythms on immune responses in animal models, the researchers aim to uncover mechanisms that could lead to improved antiviral strategies. The study involves examining how specific proteins related to the body's internal clock affect the immune response to viruses like coxsackievirus B3. This could provide insights into optimizing treatment timing for viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for enteric virus infections, particularly those with compromised immune systems.
Not a fit: Patients who do not have enteric virus infections or those with stable immune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for timing antiviral treatments to enhance their effectiveness against enteric viruses.
How similar studies have performed: Previous studies have shown that circadian rhythms significantly influence metabolism and immune responses, suggesting that this approach could yield valuable insights, although the specific focus on enteric viruses is relatively novel.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PFEIFFER, JULIE K — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: PFEIFFER, JULIE K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.