How the body's internal clock affects diet and aging in fruit flies
Official title: Genetic Mechanisms of Circadian Clock-Mediated Dietary Restriction in Drosophila
Funded at University of Louisville · NIH-10579030 · Data updated 2026-11-12
This study is looking at how eating less food without missing out on nutrients can help us live longer and healthier, using fruit flies to understand how our body’s internal clock and diet work together to affect our health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $445,390 |
| NIH project number | 1R15AG074538-01A1 |
| Project ID | NIH-10579030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals interested in dietary interventions for aging and health promotion.
✕Less likely to help
Patients with conditions that prevent them from participating in dietary changes or those not interested in dietary interventions may not benefit from this research.
What this research studies
This research investigates how dietary restriction, which involves reducing calorie intake without causing malnutrition, can extend lifespan and improve health. Using fruit flies as a model organism, the study aims to uncover the genetic mechanisms by which the circadian clock interacts with diet and light cycles to influence metabolism and behavior. By employing advanced genetic tools and various assays, researchers will explore how these interactions can promote longevity and overall health.
Why it matters
Potential benefit: If successful, this research could lead to new insights into dietary strategies that enhance health and longevity in humans.
How similar studies have gone: Previous research has shown that dietary restriction can extend lifespan in various organisms, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Hwangbo, Dae-Sung — University of Louisville
- Study coordinator: Hwangbo, Dae-Sung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.