How the body's internal clock affects brain cell regeneration after injury
Official title: Endogenous circadian clocks regulate NG2-glia regenerative potential
Funded at Children's Research Institute · NIH-10936538 · Data updated 2026-11-12
This study is looking at how our body's internal clock affects special brain cells that help heal after a brain injury, with the goal of finding new ways to boost recovery for people who have experienced trauma to their brains.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 26, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $181,642 |
| NIH project number | 5K08NS131529-02 |
| Project ID | NIH-10936538 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 0-44 who have experienced a traumatic brain injury.
✕Less likely to help
Patients with brain injuries outside the specified age range or those with conditions unrelated to TBI may not benefit from this research.
What this research studies
This research investigates the role of the body's circadian clock in regulating the regenerative potential of NG2-glia, a type of brain cell crucial for recovery after traumatic brain injury (TBI). The study aims to understand how the molecular pathways influenced by the circadian clock can affect the proliferation and differentiation of these cells in both healthy and injured brains. By exploring these mechanisms, the research seeks to identify potential therapeutic strategies to enhance brain recovery following injury.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery outcomes for patients with traumatic brain injuries.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in cellular processes, suggesting potential for success in this novel approach.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Dean, Terry — Children's Research Institute
- Study coordinator: Dean, Terry
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.