How the body's internal clock affects asthma in children as they grow up
The circadian clock as an age sensor in asthma resolution
This study is looking at how the body's natural clock affects how kids' immune systems respond to respiratory viruses and how this might help reduce asthma symptoms as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10979249 on NIH RePORTER |
What this research studies
This research investigates how the body's circadian clock influences the immune response to respiratory viruses in children and its role in asthma resolution. The study aims to understand why asthma symptoms vary with age and how children may experience fewer asthma attacks as they mature. By examining the biological processes involved, particularly in immune cells like alveolar macrophages, the research seeks to identify mechanisms that could promote asthma remission. The approach includes analyzing the timing of immune responses and their relationship to asthma exacerbations.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adolescents with a diagnosis of asthma.
Not a fit: Patients with asthma who are not within the pediatric or adolescent age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting asthma remission in children and potentially in adults.
How similar studies have performed: Previous research has shown that understanding the immune response to respiratory viruses can lead to significant advancements in asthma treatment, suggesting this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Haspel, Jeffrey Adam — Washington University
- Study coordinator: Haspel, Jeffrey Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.