How the body's internal clock affects asthma in children as they grow up
Official title: The circadian clock as an age sensor in asthma resolution
Funded at Washington University · NIH-10979249 · Data updated 2026-11-12
This study is looking at how the body's natural clock affects how kids' immune systems respond to respiratory viruses and how this might help reduce asthma symptoms as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $777,497 |
| NIH project number | 1R01HL172823-01A1 |
| Project ID | NIH-10979249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adolescents with a diagnosis of asthma.
✕Less likely to help
Patients with asthma who are not within the pediatric or adolescent age range may not benefit from this research.
What this research studies
This research investigates how the body's circadian clock influences the immune response to respiratory viruses in children and its role in asthma resolution. The study aims to understand why asthma symptoms vary with age and how children may experience fewer asthma attacks as they mature. By examining the biological processes involved, particularly in immune cells like alveolar macrophages, the research seeks to identify mechanisms that could promote asthma remission. The approach includes analyzing the timing of immune responses and their relationship to asthma exacerbations.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting asthma remission in children and potentially in adults.
How similar studies have gone: Previous research has shown that understanding the immune response to respiratory viruses can lead to significant advancements in asthma treatment, suggesting this approach has potential for success.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Haspel, Jeffrey Adam — Washington University
- Study coordinator: Haspel, Jeffrey Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.