How the body's immune system affects brain inflammation
Innate immune regulation of neuroinflammation
This study is looking at how certain immune cells in your body affect inflammation in the brain, which can be related to diseases like Alzheimer's and Multiple Sclerosis, and it hopes to find new ways to treat these conditions by understanding and adjusting these immune responses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11077678 on NIH RePORTER |
What this research studies
This research investigates the role of the innate immune system in regulating inflammation within the central nervous system, which is linked to various neurodegenerative diseases such as Alzheimer's and Multiple Sclerosis. The study aims to explore how T cells, a type of immune cell, contribute to inflammation and whether manipulating these responses can lead to new treatments. By using innovative methods and translating findings from animal models to human samples, the research seeks to uncover new therapeutic strategies for managing neuroinflammation and its associated cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related cognitive decline or diagnosed with neurodegenerative diseases like Alzheimer's or Multiple Sclerosis.
Not a fit: Patients with acute neuroinflammatory conditions or those not experiencing cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse cognitive decline associated with neurodegenerative diseases.
How similar studies have performed: Previous research has shown promise in understanding immune responses in neuroinflammation, suggesting that this approach could yield significant advancements.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Sonnenberg, Gregory F — Weill Medical Coll of Cornell Univ
- Study coordinator: Sonnenberg, Gregory F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.