How the body's daily rhythms affect viral gene delivery
The circadian rhythm as a lentiviral vector restriction factor
This study is looking at how our body's natural daily rhythms can affect the success of gene therapy, which might help make these treatments work better for patients with different health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10675626 on NIH RePORTER |
What this research studies
This research investigates how circadian rhythms, which are the natural daily cycles of biological processes, influence the effectiveness of lentiviral vectors used in gene therapy. By examining the timing of viral application and the role of specific genes related to these rhythms, the study aims to understand how these factors can enhance or restrict the delivery of therapeutic genes to cells. Patients may benefit from insights that could improve gene therapy techniques, making them more effective for treating various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals undergoing gene therapy for conditions related to cancer or genetic disorders.
Not a fit: Patients who are not undergoing gene therapy or do not have conditions affected by viral vectors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies by optimizing the timing of treatment based on patients' circadian rhythms.
How similar studies have performed: While the effects of circadian rhythms on viral infections have been studied, the specific impact on lentiviral vector transduction is a novel area of investigation.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Kafri, Tal — Univ of North Carolina Chapel Hill
- Study coordinator: Kafri, Tal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.