How the body manages potassium and acid-base balance
Coordinated SLC12A3/SLC12A6/SL26A4 electroneutral transport pathways maintain K+ homeostasis and acid-base balance
This work helps us understand how our bodies control potassium levels and maintain a healthy acid-base balance, especially when we eat alkaline foods or experience alkalosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11124836 on NIH RePORTER |
What this research studies
Our bodies work hard to keep potassium levels and acid-base balance just right, but we don't fully understand how this happens, especially with alkaline diets or conditions like alkalosis. This project looks at specific pathways in the kidneys that move potassium and other substances. We want to learn how these pathways are activated and how they work together to keep our bodies in balance. This knowledge could help us better understand and treat conditions where these balances are off.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but it aims to benefit individuals who experience issues with potassium levels or acid-base imbalances.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how the body regulates potassium and acid-base balance, potentially guiding future treatments for related disorders.
How similar studies have performed: This project builds on a recent discovery of a key potassium transport pathway, suggesting a novel approach to a long-standing question.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Delpire, Eric J — Vanderbilt University Medical Center
- Study coordinator: Delpire, Eric J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.