How the body heals the intestines after radiation damage
Official title: STING-dependent Intestinal Regeneration upon Radiation Injury
Funded at University of Southern California · NIH-10799622 · Data updated 2026-11-12
This study is looking at how the gut can heal itself after being hurt by radiation, focusing on how certain immune signals help the healing process, which could lead to better treatments for people dealing with radiation-related gut issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $474,148 |
| NIH project number | 5R01CA260900-04 |
| Project ID | NIH-10799622 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who have experienced gastrointestinal injury due to radiation therapy or exposure.
✕Less likely to help
Patients with gastrointestinal injuries not related to radiation exposure may not benefit from this research.
What this research studies
This research investigates how the intestinal lining, which is crucial for digestion and nutrient absorption, can regenerate after being damaged by radiation. It focuses on understanding the role of specific immune signals in promoting healing and recovery of intestinal stem cells following radiation exposure. By studying the effects of a protein called STING and its relationship with inflammation, the research aims to identify potential treatments that could improve recovery for patients suffering from radiation-induced intestinal injuries. The approach includes using animal models to observe the healing process and the impact of immune responses on regeneration.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance intestinal recovery for patients undergoing radiation therapy or those affected by radiation exposure.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in tissue regeneration, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Yu, Jian — University of Southern California
- Study coordinator: Yu, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.