How the body controls a specific amino acid related to aging and cell health
Official title: Epitranscriptomic control of ROS
Funded at Suny Polytechnic Institute · NIH-10523266 · Data updated 2026-11-12
This study is looking at how a special amino acid called selenocysteine helps keep our cells healthy and may prevent aging, by examining how changes in a type of RNA affect the production of enzymes that clean up harmful substances in our bodies, and it's for anyone interested in understanding more about aging and related health issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Suny Polytechnic Institute NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | August 24, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $459,347 |
| NIH project number | 1R15CA274603-01 |
| Project ID | NIH-10523266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in understanding the biological processes of aging and those with conditions related to oxidative stress.
✕Less likely to help
Patients with acute conditions unrelated to aging or oxidative stress may not benefit from this research.
What this research studies
This research investigates the role of a unique amino acid called selenocysteine in maintaining cellular health and preventing aging-related damage. It focuses on how changes in the modification of transfer RNA (tRNA) affect the production of enzymes that detoxify harmful molecules in the body. By studying both human cells and specially engineered mice, the researchers aim to understand how defects in these processes can lead to cellular aging and related diseases. The study employs a combination of molecular, biochemical, and genomic techniques to explore these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing age-related diseases and improving overall cellular health.
How similar studies have gone: Previous research has shown promising results in understanding the role of amino acids in cellular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Suny Polytechnic Institute
Albany, United States Active
Researchers
- Principal investigator: Carpenter, Michael — Suny Polytechnic Institute
- Study coordinator: Carpenter, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.