How the body boosts blood cell production during stress and disease
Emergency Myelopoiesis in the Control of Blood Production
This project looks at how bone marrow switches into an emergency mode to rapidly make myeloid blood cells during infections, chronic inflammation, aging, and blood cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11311847 on NIH RePORTER |
What this research studies
From my perspective as a patient, the team will study how stem and progenitor cells in bone marrow change their gene activity, metabolism, and behavior when the body demands lots of immune cells quickly. They will use laboratory models and a new “bone marrow‑on‑chip” platform to mimic the bone marrow environment and see how niche signals drive emergency myelopoiesis. The researchers will also connect these emergency pathways to trained immunity, the variety of myeloid cell types made, and how tumors create suppressive immune environments. Results will come from molecular analyses of cells and controlled lab systems rather than testing a new drug in patients.
Who could benefit from this research
Good fit: People with blood cancers, chronic inflammatory conditions, age‑related immune changes, or those willing to donate blood or bone marrow samples would be most relevant to this research.
Not a fit: Patients seeking an immediate new therapy would likely not benefit directly, since this is laboratory‑focused research rather than a treatment trial.
Why it matters
Potential benefit: If successful, this work could reveal targets to prevent harmful overproduction of inflammatory or immune‑suppressing myeloid cells and lead to better treatments for infections, age‑related immune problems, and some cancers.
How similar studies have performed: Prior studies have described emergency myelopoiesis pathways in lab and animal work, but applying a bone marrow‑on‑chip to model niche–stem cell interactions is a newer, less tested approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Passegue, Emmanuelle — Columbia University Health Sciences
- Study coordinator: Passegue, Emmanuelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.