How the BAF protein complex affects B cells and lymphoma
Role of chromatin remodeling complex BAF in immunity and lymphoma
This project looks at how changes in the BAF protein complex alter B cells and may drive diffuse large B-cell lymphoma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11190983 on NIH RePORTER |
What this research studies
If you have a B-cell lymphoma, researchers will study how the BAF protein complex controls germinal center B cells, which can give rise to diffuse large B-cell lymphoma. They will examine BAF complex composition, where BAF binds on the genome, and how those changes alter chromatin accessibility using genomics and computational analyses on primary cells carrying patient-like BAF mutations. Laboratory experiments will also test how BAF influences nucleosome positioning and B-cell proliferation in models derived from patient samples. The work combines patient-derived samples, sequencing-based assays, and computational methods to link molecular changes to lymphoma-related cell behavior.
Who could benefit from this research
Good fit: Ideal participants would be people with diffuse large B-cell lymphoma or related B-cell disorders who can provide tumor tissue or blood samples for molecular studies.
Not a fit: Patients seeking immediate new treatments or those with cancers unrelated to B cells or BAF mutations are unlikely to receive direct clinical benefit from this research.
Why it matters
Potential benefit: A clearer understanding of how BAF mutations drive lymphoma could point to new diagnostic markers or targets for therapies for DLBCL patients.
How similar studies have performed: Genomic and chromatin-mapping approaches have been successfully used in cancer research, but applying them specifically to BAF's role in germinal center B cells and DLBCL remains relatively new.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Barisic, Darko — Weill Medical Coll of Cornell Univ
- Study coordinator: Barisic, Darko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.