How the appendix may influence Parkinson's disease
The contribution of the vermiform appendix to Parkinson's disease
This study is looking at how the appendix might be linked to Parkinson's disease by checking for certain changes in people with the condition compared to those who are healthy, hoping to find ways to help prevent or treat Parkinson's earlier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10874663 on NIH RePORTER |
What this research studies
This research investigates the role of the appendix in the development of Parkinson's disease (PD), focusing on how alpha-synuclein aggregates found in the appendix may contribute to the disease's onset. The study aims to analyze gene regulatory changes in the appendix of PD patients compared to healthy individuals, exploring the connection between gastrointestinal health and neurological symptoms. By understanding these mechanisms, the research seeks to uncover potential pathways for early intervention or prevention of PD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Parkinson's disease or those experiencing early gastrointestinal symptoms.
Not a fit: Patients who have already been diagnosed with advanced Parkinson's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying the onset of Parkinson's disease.
How similar studies have performed: This research builds on previous findings that suggest a link between gastrointestinal health and Parkinson's disease, indicating a novel approach to understanding the disease.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Brundin, Lena Cecilia — Van Andel Research Institute
- Study coordinator: Brundin, Lena Cecilia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.