How the APOE4 gene affects brain changes after repeated mild traumatic brain injuries.
Official title: Influence of APOE4 genotype on microglial pathobiology and tau pathology after repetitive mTBI
Funded at Roskamp Institute, INC. · NIH-10746837 · Data updated 2026-11-12
This study is looking at how a specific gene called APOE4 might affect brain changes after repeated mild head injuries, helping us understand the risks for developing Alzheimer's disease in people with this gene.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roskamp Institute, INC. NIH-funded |
| Lab location | 1 site (Sarasota, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $163,440 |
| NIH project number | 5R03AG080415-02 |
| Project ID | NIH-10746837 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of repetitive mild traumatic brain injuries, particularly those who carry the APOE4 allele.
✕Less likely to help
Patients who do not have a history of mild traumatic brain injuries or do not carry the APOE4 allele may not benefit from this research.
What this research studies
This research investigates the impact of the APOE4 genotype on brain changes following repetitive mild traumatic brain injuries (r-mTBI). It focuses on understanding how this genetic factor may influence the development of tau pathology, which is linked to Alzheimer's disease. Using well-characterized animal models, the study aims to identify the molecular triggers that lead to neurodegenerative changes associated with r-mTBI. By examining these models, researchers hope to draw connections to human cases and improve our understanding of the risks associated with the APOE4 allele.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for individuals at risk of Alzheimer's disease following brain injuries.
How similar studies have gone: While the role of APOE in TBI outcomes has been studied, this research aims to provide novel insights using controlled animal models, which may not have been extensively explored before.
Where this research is happening
-
Roskamp Institute, INC.
Sarasota, United States Active
Researchers
- Principal investigator: Ojo, Joseph O — Roskamp Institute, INC.
- Study coordinator: Ojo, Joseph O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.