How the amygdala affects breathing control
Amygdala modulation of volitional versus automatic breathing
This study is looking at how a part of the brain called the amygdala affects breathing during seizures, especially to help find ways to prevent sudden unexpected death in epilepsy (SUDEP) for people with epilepsy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10992643 on NIH RePORTER |
What this research studies
This research investigates the role of the amygdala in regulating both voluntary and automatic breathing, particularly in the context of sudden unexpected death in epilepsy (SUDEP). By studying the mechanisms that lead to breathing inhibition during seizures, the research aims to uncover potential preventive strategies for patients at risk of SUDEP. The approach involves a combination of clinical insights and animal models to better understand the neural control of respiration. Patients may benefit from advancements in treatment options that could arise from this understanding.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with refractory epilepsy who are at risk for sudden unexpected death.
Not a fit: Patients with well-controlled epilepsy or those not experiencing seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing sudden unexpected death in epilepsy, improving safety for patients with refractory epilepsy.
How similar studies have performed: Previous research has indicated that understanding the neural mechanisms of breathing control can lead to significant advancements in treating conditions related to respiratory dysfunction, suggesting potential for success in this area.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Dlouhy, Brian J — University of Iowa
- Study coordinator: Dlouhy, Brian J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.