How the ABI3 gene might affect Alzheimer's
The role of ABI3 in Alzheimers disease
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11175531
Researchers are testing whether changes in the ABI3 gene alter brain immune cells and contribute to late‑onset Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11175531 on ClinicalTrials.gov |
What this research studies
This project focuses on ABI3, a gene linked to higher risk of late‑onset Alzheimer's, and its role in microglia (the brain's immune cells). The team will use mouse models that lack ABI3 and mice carrying the human ABI3 risk variant to look for changes in brain pathology, amyloid, and cell function. They will analyze gene and protein changes, do brain imaging and electrophysiology, and examine brain tissue for disease markers. The goal is to find the pathways by which ABI3 changes affect Alzheimer's biology and identify possible targets for future therapies.
Who could benefit from this research
Good fit: Findings would be most relevant to people with late‑onset Alzheimer's or those with a family history or known ABI3 risk variant.
Not a fit: People without Alzheimer's or whose disease is driven by unrelated causes may not see direct benefits from this preclinical work.
Why it matters
Potential benefit: If successful, the work could point to new microglia‑focused targets for treatments that slow or prevent Alzheimer's progression.
How similar studies have performed: Genetic studies have linked ABI3 to Alzheimer's risk, but functional and therapeutic research is still early and mainly in animal models.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, JUNGSU — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: KIM, JUNGSU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease