How the 3D structure of our genome responds to physical stresses in health and disease
Folding, Misfolding, and Unfolding: How human 3D genome structure resists, adapts, or succumbs to physical stresses in health and disease
This study looks at how the way our chromosomes are folded in the cell's nucleus affects important processes like how genes work and how our bodies fix DNA damage, helping us understand what keeps our chromosomes healthy, especially when they face stress or mutations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project ID | NIH-10842538 on NIH RePORTER |
What this research studies
This research investigates how the three-dimensional folding of human chromosomes within the nucleus affects important biological processes like gene regulation and DNA repair. By examining how the genome structure responds to various physical stresses, such as DNA damage and changes in the nucleus caused by mutations, the research aims to uncover the mechanisms that maintain chromosome integrity. The study utilizes advanced techniques to analyze how these structural changes can influence cell behavior and health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that involve chromosomal abnormalities, such as certain cancers or heart diseases.
Not a fit: Patients with conditions unrelated to chromosomal structure or those who do not have any genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how chromosome structure impacts diseases like cancer and cardiomyopathies, potentially guiding new treatment strategies.
How similar studies have performed: Previous research has shown promising results in understanding the role of chromosome structure in health and disease, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Knoxville, United States
- University of Tennessee Knoxville — Knoxville, United States (Active)
Researchers
- Principal investigator: Mccord, Rachel Patton — University of Tennessee Knoxville
- Study coordinator: Mccord, Rachel Patton
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.