How the 3D structure of genomes affects long-term memory in the brain
From 3D genomes to neural connectomes: Higher-order chromatin mechanisms encoding long-term memory
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-10891447
This study is looking at how the shape of our genes affects how our brain works and helps us remember things, with the hope of finding new ways to help people with memory problems or brain disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10891447 on ClinicalTrials.gov |
What this research studies
This research investigates the complex ways in which the three-dimensional structure of genomes influences gene expression and memory formation in the brain. By utilizing advanced molecular and computational techniques, the team aims to understand how chromatin folding and epigenetic modifications contribute to the functioning of neural circuits. The study will explore how these mechanisms can be manipulated to address synaptic defects associated with neurological disorders, potentially leading to new therapeutic strategies. Patients may benefit from insights gained about memory encoding and the underlying genetic factors involved in brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurological disorders that affect memory, such as fragile X syndrome or other degenerative conditions.
Not a fit: Patients with acute neurological injuries or those without any cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for memory-related disorders and improve our understanding of brain function.
How similar studies have performed: Other research has shown promising results in understanding the role of genome structure in brain function, suggesting that this approach could yield significant insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PHILLIPS-CREMINS, JENNIFER ELIZABETH — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: PHILLIPS-CREMINS, JENNIFER ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.