How THC Affects Immune Cells in People with HIV
In vivo study of THC-induced immunogenome changes at single cell resolution in HIV-infected humans
This research explores how THC, a component of cannabis, changes immune cells in people living with HIV to see if it can help reduce inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10870076 on NIH RePORTER |
What this research studies
Chronic HIV infection often causes ongoing immune activation, which can lead to other health problems. While some studies suggest cannabinoids might reduce inflammation, their exact effects in people with HIV are not fully clear. This project aims to understand precisely how THC affects different types of immune cells at a very detailed level. Researchers will look at changes in genes and cell activity in people with and without HIV who receive THC.
Who could benefit from this research
Good fit: Ideal candidates would be individuals living with HIV and healthy volunteers interested in participating in a study involving THC administration.
Not a fit: Patients who are not living with HIV or who cannot safely take THC would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to manage inflammation and improve health outcomes for people living with HIV.
How similar studies have performed: While some prior work suggests cannabinoids have immune effects, the specific mechanisms in HIV infection are not well understood, making this a novel approach to clarify contradictory findings.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Xu, Ke — Yale University
- Study coordinator: Xu, Ke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.