How TGFβ family proteins affect ovarian and uterine health
Transforming growth factor β family signaling pathways in ovarian and uterine biology
Researchers are looking at how a group of proteins called TGFβ control cells in the ovaries and uterus to help people with infertility, preeclampsia, or endometriosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11226660 on NIH RePORTER |
What this research studies
This project uses genetic and chemical approaches to map how TGFβ family ligands, receptors, and downstream signals work in the ovary and uterus. The team has created hundreds of mouse models and combines mouse genetics with molecular experiments to trace signaling paths that control fertility and reproductive tract health. They are also beginning to develop specific kinase inhibitors that target TGFβ family receptors as potential therapies. The work is aimed at conditions such as infertility, preeclampsia, and endometriosis and connects basic lab findings to possible clinical applications.
Who could benefit from this research
Good fit: People with infertility, repeated pregnancy problems, preeclampsia risk, or symptomatic endometriosis would be the most relevant for future clinical work stemming from this research.
Not a fit: People without reproductive tract conditions or those seeking treatments for unrelated diseases are unlikely to see direct benefits from this project.
Why it matters
Potential benefit: If successful, this research could point to new drug targets or tests that improve diagnosis and treatment of infertility, preeclampsia, and endometriosis.
How similar studies have performed: Prior genetic and molecular studies from this group and others have identified key oocyte signals (like GDF9 and BMP15) and produced strong preclinical results, while translation to clinical therapies is still emerging.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Matzuk, Martin M. — Baylor College of Medicine
- Study coordinator: Matzuk, Martin M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.