How Tet enzymes control gene regulation in embryonic stem cells
Official title: Epigenetic regulation of embryonic stem cell biology by Tet enzymes
Funded at Albert Einstein College of Medicine · NIH-11011071 · Data updated 2026-11-12
This study looks at how certain enzymes help control gene activity in embryonic stem cells, which could lead to better stem cell treatments and advancements in regenerative medicine for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $462,000 |
| NIH project number | 1R35GM156415-01 |
| Project ID | NIH-11011071 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals interested in stem cell therapies or those affected by conditions that could be treated with regenerative medicine.
✕Less likely to help
Patients with conditions unrelated to stem cell biology or those not seeking regenerative therapies may not receive direct benefits from this research.
What this research studies
This research investigates the role of Tet enzymes in regulating gene expression in embryonic stem cells (ESCs) through epigenetic mechanisms. It focuses on how these enzymes modify DNA methylation, which is crucial for the proper functioning and development of ESCs. By examining the stepwise oxidation of 5-methylcytosine and its implications for gene regulation, the research aims to uncover new insights into the developmental potential of these cells. Patients may benefit from understanding how these mechanisms can influence stem cell therapies and regenerative medicine.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for utilizing embryonic stem cells in regenerative medicine and disease treatment.
How similar studies have gone: Other research has shown promising results in understanding the role of epigenetic mechanisms in stem cell biology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Dawlaty, Meelad — Albert Einstein College of Medicine
- Study coordinator: Dawlaty, Meelad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.