How testosterone and training affect recovery after spinal cord injury
Influence of aromatase on neuromuscular plasticity resulting from testosterone plus locomotor training after spinal cord injury
This study is looking at how using testosterone along with special treadmill exercises can help people recover better from spinal cord injuries, and it aims to find the smallest amount of testosterone that works well without causing unwanted side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11267213 on NIH RePORTER |
What this research studies
This research investigates how combining testosterone treatment with bodyweight-supported treadmill training can improve recovery from spinal cord injuries. It aims to find the lowest effective dose of testosterone that enhances motor function while minimizing side effects like prostate enlargement. The study also explores the role of estradiol, a hormone derived from testosterone, in promoting nerve and muscle recovery. By using a rodent model, the research seeks to understand the mechanisms behind these treatments and their potential benefits for improving movement after injury.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with spinal cord injuries who experience motor dysfunction and are seeking innovative rehabilitation options.
Not a fit: Patients with spinal cord injuries who do not respond to hormonal treatments or have contraindications for testosterone therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved rehabilitation strategies for individuals recovering from spinal cord injuries, enhancing their mobility and quality of life.
How similar studies have performed: Previous research has shown promising results with similar approaches, indicating potential for significant advancements in rehabilitation techniques for spinal cord injuries.
Where this research is happening
Gainesville, United States
- Veterans Health Administration — Gainesville, United States (Active)
Researchers
- Principal investigator: Otzel, Dana M — Veterans Health Administration
- Study coordinator: Otzel, Dana M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.