How testosterone affects insulin secretion in men
Official title: Role of the Androgen Receptor in Insulin Secretion in the Male
Funded at Southeast Louisiana Veterans Health Care · NIH-10867257 · Data updated 2026-11-12
This study is looking at how testosterone affects insulin production in men and how low levels of testosterone might contribute to type 2 diabetes, with the hope of finding new ways to help treat diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southeast Louisiana Veterans Health Care NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| NIH project number | 5I01BX005812-02 |
| Project ID | NIH-10867257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men experiencing testosterone deficiency or those at risk for type 2 diabetes.
✕Less likely to help
Patients who are women or those without testosterone deficiency may not benefit from this research.
What this research studies
This research investigates the role of testosterone and its receptor in enhancing insulin secretion from pancreatic cells in men. It aims to understand how testosterone deficiency may lead to type 2 diabetes by studying the mechanisms involved in insulin production and secretion. The researchers will use both animal models and human pancreatic cells to explore how testosterone interacts with glucagon-like peptide-1 to improve insulin response. This study could provide insights into new treatment strategies for diabetes in men.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for type 2 diabetes in men by targeting testosterone pathways.
How similar studies have gone: Previous research has shown promising results in understanding the role of testosterone in insulin secretion, indicating that this approach has potential for success.
Where this research is happening
-
Southeast Louisiana Veterans Health Care
New Orleans, United States Active
Researchers
- Principal investigator: Mauvais-Jarvis, Franck — Southeast Louisiana Veterans Health Care
- Study coordinator: Mauvais-Jarvis, Franck
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.