How temperature affects fertility in nematodes
Temperature-sensitive germline structures and temperature thresholds of fertility in Caenorhabditis nematodes
['FUNDING_R15'] · MARQUETTE UNIVERSITY · NIH-10875984
This study looks at how high temperatures affect the ability of tiny worms called nematodes to reproduce, helping us understand which parts of their reproductive system might struggle in the heat.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MARQUETTE UNIVERSITY (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10875984 on ClinicalTrials.gov |
What this research studies
This research investigates how elevated temperatures impact fertility in Caenorhabditis nematodes, a model organism for studying reproductive biology. The study focuses on specific germline structures that may fail under temperature stress, potentially leading to infertility. By comparing different species of nematodes with varying thermal limits, researchers aim to identify the critical structures involved in this temperature-sensitive fertility loss. The approach includes examining the synaptonemal complex and germ granules, which are essential for fertility and may exhibit temperature-dependent failures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of fertility, particularly those affected by environmental factors.
Not a fit: Patients with fertility issues unrelated to temperature or those not interested in the biological aspects of fertility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of fertility mechanisms and inform strategies to mitigate fertility issues related to temperature stress.
How similar studies have performed: While this research explores a novel approach in nematodes, similar studies in other species have shown that temperature can significantly impact fertility, suggesting potential relevance.
Where this research is happening
MILWAUKEE, UNITED STATES
- MARQUETTE UNIVERSITY — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PETRELLA, LISA NICOLE — MARQUETTE UNIVERSITY
- Study coordinator: PETRELLA, LISA NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.