How telomeres and a specific protein complex interact in human cells
The interplay of the CST complex and telomerase at human telomeres
['FUNDING_OTHER'] · ROCKEFELLER UNIVERSITY · NIH-10977201
This study is looking at how certain parts of our cells, called telomeres, can affect cancer and other diseases, and it aims to find new ways to help people with conditions like dyskeratosis congenita by understanding how a specific protein complex helps keep these telomeres healthy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10977201 on ClinicalTrials.gov |
What this research studies
This research investigates the role of telomeres, which are protective caps on the ends of chromosomes, in the development of cancer and other diseases. It focuses on a protein complex called CST that helps maintain telomeres and regulates telomerase, an enzyme that can contribute to cancer when telomeres are excessively long. By understanding how these components interact, the research aims to uncover mechanisms that could lead to better treatments for conditions associated with telomere dysfunction, such as dyskeratosis congenita and various cancers. Patients may benefit from insights that could lead to new therapeutic strategies targeting telomere maintenance.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions like dyskeratosis congenita or Coats plus syndrome, as well as those at risk for cancers associated with telomere length abnormalities.
Not a fit: Patients without any genetic predisposition to telomere-related diseases or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancers and genetic disorders related to telomere dysfunction.
How similar studies have performed: Other research has shown promising results in understanding telomere biology and its implications for cancer, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAKAI, HIROYUKI — ROCKEFELLER UNIVERSITY
- Study coordinator: TAKAI, HIROYUKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Coats plus disease, Coats plus syndrome, Cole syndrome, Cole-Rauschkolb-Toomey syndrome