How teens and young adults misuse prescription drugs and other substances over time

Longitudinal Changes in Prescription Drug Misuse and Polysubstance Use in Adolescents and Young Adults

NIH-funded research Texas State University · NIH-11146555

This work looks at patterns of prescription drug misuse and mixing with other substances in teens and young adults to find who is most at risk.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionTexas State University NIH-funded
Lab location1 site (San Marcos, United States)
Project IDNIH-11146555 on NIH RePORTER

What this research studies

This project uses large, nationally collected surveys (Monitoring the Future and NSDUH) that include thousands of people aged about 12–30 to study prescription drug misuse over time. Researchers will examine differences by age, birth cohort, and calendar period and will describe who misuses multiple medication classes and who mixes prescription drugs with alcohol or other drugs. They will also look at motives, sources of medications, age when misuse starts, and signs of substance use disorder. The goal is to turn these patterns into clearer targets for screening, prevention, and policy.

Who could benefit from this research

Good fit: Teens and young adults roughly aged 12–30, especially those who have used prescription medicines without a prescription or combined them with alcohol or other drugs.

Not a fit: People older than about 30 or those whose substance concerns involve only non-prescription illegal drugs with no prescription medication misuse may not see direct benefits.

Why it matters

Potential benefit: If successful, the findings could help doctors, schools, and public-health programs better identify at-risk youth and reduce overdoses and long-term harms.

How similar studies have performed: National surveys have described rates of prescription misuse before, but combining age-period-cohort analysis with detailed multi-class and polysubstance misuse patterns is less common and fairly new.

Where this research is happening

San Marcos, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.