How tau protein mutations affect memory in fronto-temporal dementia
Contributions of tau-mediated translational dysregulation to pathogenesis and progression of fronto-temporal dementia
This study is looking at how changes in a protein called tau might lead to memory problems in people with fronto-temporal dementia, and it aims to find new ways to help improve memory for those affected by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11021037 on NIH RePORTER |
What this research studies
This research investigates the role of tau protein mutations in causing memory impairment associated with fronto-temporal dementia (FTD). By examining human brain tissues and using animal models, the study aims to understand how abnormal tau interacts with ribosomal complexes and disrupts protein synthesis critical for memory function. The researchers will explore the mechanisms behind this interaction and its implications for developing targeted therapies for FTD. The ultimate goal is to uncover new therapeutic strategies that could improve outcomes for individuals affected by this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with fronto-temporal dementia, particularly those with tau protein mutations.
Not a fit: Patients without fronto-temporal dementia or those with other types of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory function in patients with fronto-temporal dementia.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that targeting tau-related mechanisms can lead to promising therapeutic advancements in neurodegenerative diseases.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Abisambra, Jose Francisco — University of Florida
- Study coordinator: Abisambra, Jose Francisco
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.