How tamoxifen helps muscles recover after spinal cord injuries
Effects of Tamoxifen in skeletal muscle recovery after spinal cord injury and mechanisms activated by the drug
This study is looking at how the cancer drug tamoxifen might help muscles recover better after a spinal cord injury, especially during the early days when you can't exercise, and it will also check if there are any differences in how men and women respond to the treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Med Sciences NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project ID | NIH-11060018 on NIH RePORTER |
What this research studies
This research investigates the effects of tamoxifen, a cancer drug, on muscle recovery following spinal cord injuries. It aims to understand how tamoxifen can reduce muscle degeneration and improve muscle function during the critical early phase after injury when exercise is not possible. The study will explore the drug's impact on muscle fiber properties and the activation of satellite cells, with a focus on potential differences between male and female responses. By using animal models, the research seeks to provide insights that could lead to new therapeutic strategies for patients with spinal cord injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently suffered a spinal cord injury and are experiencing muscle atrophy.
Not a fit: Patients with chronic spinal cord injuries or those who do not have significant muscle atrophy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery of muscle function in patients with spinal cord injuries.
How similar studies have performed: While the use of tamoxifen for muscle recovery is a novel approach, preliminary data suggests it may have beneficial effects, indicating potential for success.
Where this research is happening
San Juan, United States
- University of Puerto Rico Med Sciences — San Juan, United States (Active)
Researchers
- Principal investigator: Miranda, Jorge David — University of Puerto Rico Med Sciences
- Study coordinator: Miranda, Jorge David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.