How T cells sense mechanical force to recognize targets
Computational Analysis of TCR Load Propagation and Dynamics
Using computer models, researchers will learn how T cell receptors change when they touch other cells so immune responses to infections and cancer can improve.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11253693 on NIH RePORTER |
What this research studies
Researchers will use advanced computer simulations to model how the αβ T‑cell receptor (TCR) behaves when it binds peptide‑presenting molecules on other cells. They will measure strains and stresses across the dynamically fluctuating TCR‑pMHC complex to map the pathway by which mechanical load propagates. A separate set of simulations will search for loading conditions that cause parts of the TCR to partially unfold and enter a 'volleying' state that can strengthen binding under force. Although computational, the work aims to explain why T cells can detect rare antigens on antigen‑presenting cells, which is important for infection and cancer immunity.
Who could benefit from this research
Good fit: People with cancers or chronic infections who might receive T cell–based therapies are the most relevant long‑term beneficiaries of this work.
Not a fit: This project does not provide direct treatment, so patients seeking immediate therapy or clinical care should not expect personal benefit from the research itself.
Why it matters
Potential benefit: If successful, this could guide design of better T cell–based immunotherapies and vaccines that more reliably recognize infected or cancerous cells.
How similar studies have performed: Laboratory experiments and earlier molecular simulations support the idea that TCRs act as mechanosensors, but using that knowledge to improve therapies is still early‑stage.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Hwang, Wonmuk — Dana-Farber Cancer Inst
- Study coordinator: Hwang, Wonmuk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.