How T cells interact with aging cells in the body
T cell surveillance of senescent cells under homeostasis and aging
This study is looking at how T cells, a type of immune cell, can find and get rid of old, non-dividing cells that can make us age and get sick, to help us stay healthier as we grow older.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11031844 on NIH RePORTER |
What this research studies
This research investigates the role of T cells in recognizing and eliminating senescent cells, which are cells that have stopped dividing and can contribute to aging and various diseases. The study aims to understand how these aging cells communicate with T cells to either activate or inhibit their function. By examining the molecular mechanisms involved, the research seeks to uncover how T cells can effectively target and eliminate senescent cells, potentially improving health outcomes as we age.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or conditions associated with cellular senescence.
Not a fit: Patients who are younger and do not have age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune system's ability to clear aging cells, potentially improving health and longevity.
How similar studies have performed: Previous research has shown promising results in understanding T cell interactions with senescent cells, indicating that this approach has potential for significant advancements.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Sturmlechner, Ines — Mayo Clinic Rochester
- Study coordinator: Sturmlechner, Ines
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.