How T cells find and target specific tissues in immunotherapy
Mechanisms and consequences of antigen-dependent T cell homing for adoptive immunotherapies
This study is looking at how to guide special immune cells called CAR T cells to the right places in the body to better fight infections, tumors, and autoimmune diseases, with the hope of making treatments more effective for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10907570 on NIH RePORTER |
What this research studies
This research investigates how T cells, particularly CAR T cells, can be effectively directed to specific tissues in the body to enhance the treatment of infections, tumors, and autoimmune conditions. By studying the interaction between T cells and endothelial cells, the research aims to understand the mechanisms that facilitate T cell homing to these tissues. The approach includes in vitro experiments that simulate the conditions in the body, allowing researchers to identify key factors that influence T cell migration and effectiveness. The ultimate goal is to improve the success rates of adoptive cell therapies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing treatment for cancers or autoimmune diseases who may benefit from enhanced T cell therapies.
Not a fit: Patients with conditions not related to T cell therapies or those who are not candidates for immunotherapy may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies that better target diseases, improving outcomes for patients.
How similar studies have performed: Previous research has shown promising results in enhancing T cell targeting through similar mechanisms, indicating potential for success in this approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Pober, Jordan S — Yale University
- Study coordinator: Pober, Jordan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.