How T cells find and target specific tissues in immunotherapy
Official title: Mechanisms and consequences of antigen-dependent T cell homing for adoptive immunotherapies
Funded at Yale University · NIH-10907570 · Data updated 2026-11-12
This study is looking at how to guide special immune cells called CAR T cells to the right places in the body to better fight infections, tumors, and autoimmune diseases, with the hope of making treatments more effective for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $418,750 |
| NIH project number | 5R01AI166364-02 |
| Project ID | NIH-10907570 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients undergoing treatment for cancers or autoimmune diseases who may benefit from enhanced T cell therapies.
✕Less likely to help
Patients with conditions not related to T cell therapies or those who are not candidates for immunotherapy may not receive benefits from this research.
What this research studies
This research investigates how T cells, particularly CAR T cells, can be effectively directed to specific tissues in the body to enhance the treatment of infections, tumors, and autoimmune conditions. By studying the interaction between T cells and endothelial cells, the research aims to understand the mechanisms that facilitate T cell homing to these tissues. The approach includes in vitro experiments that simulate the conditions in the body, allowing researchers to identify key factors that influence T cell migration and effectiveness. The ultimate goal is to improve the success rates of adoptive cell therapies for patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies that better target diseases, improving outcomes for patients.
How similar studies have gone: Previous research has shown promising results in enhancing T cell targeting through similar mechanisms, indicating potential for success in this approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Pober, Jordan S — Yale University
- Study coordinator: Pober, Jordan S
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.