How T cells distinguish between healthy and diseased cells
Mechanisms of ligand discrimination by the T cell signaling machinery
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10854866
This study is looking at how T cells, which are important for fighting off illnesses, can tell the difference between healthy and sick cells, with the goal of making these immune cells even better at treating diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10854866 on ClinicalTrials.gov |
What this research studies
This research investigates how T cells, which are crucial for the immune response, can differentiate between healthy and diseased cells. It focuses on the T cell antigen receptor (TCR) signaling network, which interprets signals from the environment to activate the appropriate immune response. By understanding the mechanisms that allow T cells to discriminate between similar signals, the research aims to enhance the effectiveness of T cells in treating diseases. The study employs advanced techniques to analyze the signaling pathways and regulatory mechanisms involved in T cell activation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve immune system dysfunction, such as cancer or autoimmune diseases.
Not a fit: Patients with conditions unrelated to T cell function or those who do not have an active immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapies for various diseases, enhancing the ability of T cells to target and eliminate diseased cells.
How similar studies have performed: Previous research has shown promising results in understanding T cell signaling, indicating that this approach has potential for significant advancements in immunotherapy.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COURTNEY, ADAM — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: COURTNEY, ADAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.