How T cells and oxidative stress contribute to pregnancy complications in rats.
Official title: Nox2-derived oxidative stress produced by T cells contributes to the development of maternal syndrome in the Dahl salt-sensitive rat.
Funded at Tulane University of Louisiana · NIH-11077363 · Data updated 2026-11-12
This study is looking at how certain immune cells and stress in the body might contribute to preeclampsia, a serious condition during pregnancy, using a special type of rat to help understand what goes wrong with the placenta and kidneys.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | April 19, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL157549-04 |
| Project ID | NIH-11077363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women, particularly those with preexisting hypertension or chronic kidney disease, who are at higher risk for developing preeclampsia.
✕Less likely to help
Patients who are not pregnant or do not have risk factors for preeclampsia may not benefit from this research.
What this research studies
This research investigates the role of T cells and oxidative stress in the development of preeclampsia, a serious pregnancy complication, using a specific rat model known as the Dahl salt-sensitive rat. The study aims to understand how improper placentation leads to maternal syndrome by examining the infiltration of T cells into the kidneys and placenta. By using this animal model, researchers hope to uncover the mechanisms behind preeclampsia without the need for surgical or pharmacological interventions. The findings could provide insights into the disease process and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for preeclampsia, potentially improving outcomes for pregnant women.
How similar studies have gone: While this approach using the Dahl salt-sensitive rat model is innovative, similar studies have shown promise in understanding preeclampsia mechanisms.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Dasinger, John H — Tulane University of Louisiana
- Study coordinator: Dasinger, John H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.