How T cells affect the brain during aging and Alzheimer's disease
Impact of T cells on the CNS during aging and Alzheimer’s disease
This study is looking at how certain immune cells in the brain, called CD8+ T cells, change as we get older and how they might affect thinking and brain health in people with Alzheimer's disease, with hopes of finding new ways to help treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-10816468 on NIH RePORTER |
What this research studies
This research investigates the role of CD8+ T cells in the brain as people age and develop Alzheimer's disease. It aims to understand how these immune cells influence cognitive function and the behavior of other brain cells, particularly microglia, which are crucial for brain health. By using various mouse models, the researchers will explore the effects of removing these T cells on cognitive abilities and brain inflammation. The findings could provide insights into potential therapeutic strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or have been diagnosed with Alzheimer's disease.
Not a fit: Patients who are younger or do not have any risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and reduce the impact of Alzheimer's disease.
How similar studies have performed: Previous research has shown that targeting immune cells can influence neurodegenerative diseases, suggesting a promising avenue for this investigation.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Cook, Casey N — Mayo Clinic Jacksonville
- Study coordinator: Cook, Casey N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.