How T cells act in newborns, children, and adults with sepsis
T Cell Receptor Mediated T Cell Activation in Neonatal and Pediatric Sepsis
Researchers will look at how immune cells called T cells respond to severe infection in newborns, children, and adults to understand why sepsis affects ages differently.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project ID | NIH-11252540 on NIH RePORTER |
What this research studies
This work compares T cell memory and activation across newborns, children, and adults to see how age changes the immune response during sepsis. The team will examine immune cell interactions, including antigen-presenting cells and signals that can amplify inflammation, and will study how angiotensin II signaling affects those interactions. They will use age-based comparisons and patient-derived samples along with laboratory tests to track how T cell activation thresholds change with sepsis and age. The goal is to map immune differences that could explain why sepsis looks and behaves differently in young children versus adults.
Who could benefit from this research
Good fit: Ideal candidates would include newborns, infants, and children with sepsis and adults with sepsis, and may also include age-matched healthy volunteers for comparison.
Not a fit: People without sepsis or whose health problems are unrelated to infection-driven inflammation are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this research could point to age-tailored ways to prevent or reduce organ damage from sepsis.
How similar studies have performed: Previous research has linked immune overactivation and angiotensin II to worse outcomes in sepsis, but applying the idea of T cell memory differences across ages to sepsis is a relatively new approach.
Where this research is happening
Manhasset, United States
- Feinstein Institute for Medical Research — Manhasset, United States (Active)
Researchers
- Principal investigator: Taylor, Matthew David — Feinstein Institute for Medical Research
- Study coordinator: Taylor, Matthew David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.