How T cell microRNAs affect immune cells during obesity
Adipose T cell microRNAs (miRs) regulate macrophage function during obesity
['FUNDING_R01'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-11011457
This study is looking at how tiny molecules in T cells affect immune cells called macrophages when people are overweight, especially after eating a lot of fatty foods, and it hopes to find new ways to help treat obesity and its related health problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11011457 on ClinicalTrials.gov |
What this research studies
This research investigates the role of T cell microRNAs in regulating macrophage function in the context of obesity. It focuses on how high-fat diets influence T cell behavior and their subsequent impact on inflammation and metabolic diseases. By examining the changes in microRNA expression in T cells and their effects on macrophage types, the study aims to uncover mechanisms that contribute to obesity-related health issues. Patients may benefit from insights that could lead to new treatments for obesity and its complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity, particularly those with metabolic complications related to their condition.
Not a fit: Patients who are not affected by obesity or related metabolic disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic strategies for managing obesity and its associated metabolic disorders.
How similar studies have performed: Other research has shown promising results in understanding the role of immune cells in obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGH, UDAI P. — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: SINGH, UDAI P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.