How swelling affects immune cell function through ion channels
Immune cell regulation by swelling-activated ion channels
['FUNDING_OTHER'] · UNIVERSITY OF CHICAGO · NIH-10941896
This study is looking at how certain channels in immune cells called T lymphocytes help them grow and work properly, especially by managing calcium signals, which could lead to new ways to improve immune responses for people with immune-related conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10941896 on ClinicalTrials.gov |
What this research studies
This research investigates the role of swelling-activated ion channels in T lymphocytes, which are crucial immune cells. The team will explore how these channels contribute to the maturation and function of T cells, particularly focusing on their ability to transport calcium signals necessary for T cell development. By employing advanced techniques from various scientific fields, including genomics and electrophysiology, the researchers aim to uncover the complex interactions that regulate immune responses. This work could lead to a better understanding of immune cell behavior and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve immune dysfunction or those interested in the biological mechanisms of immune responses.
Not a fit: Patients with non-immune related conditions or those who do not have any immune system involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune cell regulation, potentially leading to new treatments for immune-related diseases.
How similar studies have performed: While the specific focus on swelling-activated ion channels in immune cells is relatively novel, there has been success in related research exploring ion channels in other cell types.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONCEPCION GONZALEZ, AXEL ROLANDO — UNIVERSITY OF CHICAGO
- Study coordinator: CONCEPCION GONZALEZ, AXEL ROLANDO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.