How surgery affects patients using medications for opioid use disorder

The Impact of Surgery on Outcomes for Patients taking Medications for Opioid Use Disorder

['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10930927

This study is looking at how medications for opioid use disorder, like buprenorphine and methadone, affect pain management and recovery for patients after surgery, so we can find better ways to help them feel comfortable and heal.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded)
Locations1 site (ANN ARBOR, UNITED STATES)
Trial IDNIH-10930927 on ClinicalTrials.gov

What this research studies

This research investigates the impact of surgical procedures on patients who are taking medications for opioid use disorder, such as buprenorphine, methadone, and naltrexone. It aims to understand how these medications influence pain management and recovery after surgery, particularly focusing on the challenges faced by patients who develop tolerance to opioid pain relievers. The study will analyze outcomes related to pain management and opioid use in a surgical context, providing evidence to guide clinical practices and improve patient care. By examining these factors, the research seeks to clarify the best practices for managing acute pain in patients undergoing surgery while on these medications.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder who are currently receiving medications like buprenorphine, methadone, or naltrexone and are scheduled for surgical procedures.

Not a fit: Patients who are not on medications for opioid use disorder or those who do not require surgical intervention may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved pain management strategies for patients with opioid use disorder undergoing surgery, enhancing their recovery and overall health outcomes.

How similar studies have performed: Previous research has indicated the need for more rigorous studies in this area, suggesting that while some guidelines exist, there is a lack of high-quality evidence to support them, making this research both necessary and potentially groundbreaking.

Where this research is happening

ANN ARBOR, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.