How sulfite exposure affects metabolism and healing in children with ulcerative colitis
Official title: Dysregulation of Epithelial Metabolism and Regeneration by Sulfite Exposure in Pediatric Ulcerative Colitis
Funded at Stanford University · NIH-10890146 · Data updated 2026-11-12
This study is looking at how sulfites, which are found in some foods, affect the health of colon cells in kids with ulcerative colitis, to help understand better ways to manage their condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $90,000 |
| NIH project number | 5K99DK136971-02 |
| Project ID | NIH-10890146 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been diagnosed with ulcerative colitis.
✕Less likely to help
Patients who do not have ulcerative colitis or are older than 11 years may not benefit from this research.
What this research studies
This research investigates the impact of sulfite exposure on the metabolism and regeneration of colon cells in children suffering from ulcerative colitis (UC). By using colon organoids derived from pediatric patients, the study aims to understand how sulfites influence mitochondrial function, which is crucial for the health of colonic stem cells. The research will analyze genetic data to identify potential vulnerabilities in the detoxification process of sulfites in the colon, providing insights into dietary factors that may affect UC management.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations and treatments for children with ulcerative colitis.
How similar studies have gone: While the specific focus on sulfite exposure in pediatric UC is novel, previous research has shown that dietary factors can significantly impact the management of inflammatory bowel diseases.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Ojo, Babajide — Stanford University
- Study coordinator: Ojo, Babajide
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.