How sugar tags on a brain protein called neurexin1 shape nerve connections
The role of heparan sulfate modification on neurexin1 in synapse development
This project looks at whether adding a sugar chain called heparan sulfate to neurexin1 helps nerve cells form and maintain connections in ways that matter for autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11240330 on NIH RePORTER |
What this research studies
Researchers will use genetically engineered mice that either lack neurexin1 or lack the heparan sulfate tag on neurexin1 to see how nerve endings form and communicate. They will examine hippocampal CA3-CA1 synapses with detailed imaging and electrical recordings to study presynaptic structure and function. By comparing modified and normal mice, the team aims to identify molecular steps that rely on the sugar modification. The goal is to connect these basic mechanisms to synapse problems linked to autistic disorder.
Who could benefit from this research
Good fit: People with autism spectrum disorder who are interested in research on the biological causes of synapse dysfunction would be the eventual group most relevant to this work.
Not a fit: This is preclinical laboratory research in mice and will not provide direct clinical treatment or immediate benefit to patients today.
Why it matters
Potential benefit: If successful, this work could reveal new molecular targets or biomarkers that guide future treatments for synaptic problems related to autism.
How similar studies have performed: Prior animal studies deleting neurexin1 isoforms have produced synaptic and behavioral changes, but the specific importance of heparan sulfate attachment is a newer finding being explored here.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Zhang, Peng — Case Western Reserve University
- Study coordinator: Zhang, Peng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.