How sugar modifications affect T cell function
Differential regulation of T cell plasma membrane proteins by N-glycan branching and clathrin-mediated endocytosis
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11092303
This study is looking at how certain sugar changes on T cells, which are important for our immune system, affect how they work and respond, with the hope of finding new ways to improve treatments for conditions related to inflammation and immune regulation.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11092303 on ClinicalTrials.gov |
What this research studies
This research investigates how specific sugar modifications on T cell surface proteins influence their behavior and function. By examining the role of N-glycosylation, a process where sugars are attached to proteins, the study aims to understand how these modifications affect T cell activation and regulation. The researchers will explore how changes in these sugar structures can impact the immune response, particularly in relation to inflammation and immune regulation. This could lead to new insights into how T cells can be manipulated for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with immune-related conditions, such as autoimmune diseases or chronic inflammatory disorders.
Not a fit: Patients with non-immune related conditions or those not experiencing any immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing or suppressing immune responses in various diseases.
How similar studies have performed: Previous research has shown that manipulating glycosylation can significantly impact immune cell function, suggesting that this approach may yield valuable insights.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MKHIKIAN, HAIK — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: MKHIKIAN, HAIK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.