How sugar changes in the immune system affect aging and HIV infection.
Official title: Glycomic Modulation of Inflammaging and Immune Functions during HIV Infection
Funded at Northwestern University at Chicago · NIH-11158456 · Data updated 2026-11-12
This study is looking at how changes in sugar molecules on antibodies might affect inflammation and aging in people with HIV who are on treatment, with the goal of finding new ways to help manage their health and reduce related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | May 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $400,000 |
| NIH project number | 2R56AG062383-06 |
| Project ID | NIH-11158456 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or those not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates how changes in sugar molecules attached to antibodies (glycomic alterations) influence inflammation and aging in individuals living with HIV who are on antiretroviral therapy (ART). The study aims to understand whether these changes contribute to increased inflammation and related health issues in these patients. By analyzing blood samples, researchers will identify specific glycomic patterns that may serve as biomarkers for predicting health complications associated with aging and HIV. The findings could lead to new strategies for managing inflammation and improving health outcomes for people living with HIV.
Why it matters
Potential benefit: If successful, this research could provide insights into new biomarkers for predicting and managing age-related health issues in people living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding glycomic alterations and their impact on inflammation, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Abdel Mohsen, Mohamed — Northwestern University at Chicago
- Study coordinator: Abdel Mohsen, Mohamed
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.