How sugar affects the harmfulness of certain bacteria in the gut
Sugar regulation of EHEC virulance
This study looks at how certain sugars and substances in our gut affect harmful bacteria like E. coli, helping us understand how these germs behave and potentially leading to better ways to prevent infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10861002 on NIH RePORTER |
What this research studies
This research investigates how specific sugars and metabolites in the gastrointestinal tract influence the virulence of enteric pathogens like E. coli. By examining the interactions between these pathogens and the gut microbiota, the study aims to understand how these bacteria sense and respond to their environment. The research utilizes biological models to explore the signaling pathways involved in this regulation, which could lead to new insights into preventing infections caused by these pathogens.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal disorders or those at risk of infections caused by enteric pathogens.
Not a fit: Patients who do not have gastrointestinal issues or are not at risk for infections from E. coli or similar pathogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by harmful bacteria in the gut.
How similar studies have performed: Previous research has shown that understanding the interactions between gut microbiota and pathogens can lead to significant advancements in infection prevention, indicating that this approach has potential for success.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Sperandio, Vanessa — University of Wisconsin-Madison
- Study coordinator: Sperandio, Vanessa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.