How Substance P affects liver injury caused by alcohol
Official title: Regulation of Ductular Reaction by Substance P during Alcohol-induced Liver Injury
Funded at Texas A&m University Health Science Ctr · NIH-10816566 · Data updated 2026-11-12
This study is looking at how a substance in the body called Substance P affects liver problems caused by alcohol, especially how it impacts certain liver cells and their response to injury, with the hope of finding better ways to treat alcohol-related liver disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $186,865 |
| NIH project number | 5R21AA030095-02 |
| Project ID | NIH-10816566 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from alcohol-associated liver disease, including conditions like alcoholic steatohepatitis and cirrhosis.
✕Less likely to help
Patients with liver diseases not related to alcohol consumption may not benefit from this research.
What this research studies
This research investigates the role of Substance P, a neuropeptide, in the progression of alcohol-associated liver disease (ALD). It focuses on how alcohol impacts biliary epithelial cells, specifically cholangiocytes, and their response to liver injury. The study aims to understand the mechanisms by which Substance P influences liver inflammation and fibrosis through specific signaling pathways. By examining these interactions, the research seeks to uncover new insights into the treatment of liver diseases related to alcohol consumption.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating alcohol-related liver diseases.
How similar studies have gone: While the role of Substance P in liver injury has been studied, the specific focus on its effects in alcohol-associated liver disease is relatively novel.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Glaser, Shannon Stroud — Texas A&m University Health Science Ctr
- Study coordinator: Glaser, Shannon Stroud
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.