How stress responses interact with the body's internal clock
Integrated stress response and the circadian clock
This study is looking at how stress and our body’s internal clock work together, which is important for keeping our brains healthy, and it aims to help people who have sleep problems or other health issues by finding ways to restore balance in these systems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10927421 on NIH RePORTER |
What this research studies
This research investigates the relationship between the integrated stress response (ISR) and the circadian clock, which are crucial for maintaining healthy brain function. By studying how these two systems communicate, the research aims to uncover mechanisms that could explain disruptions in sleep and other health issues. Using advanced mouse models, the team will employ various molecular, cellular, and behavioral techniques to explore how stress responses can affect circadian rhythms and vice versa. This could lead to a better understanding of how to restore balance in individuals experiencing related health problems.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing sleep disorders or other health problems related to circadian rhythm disruptions.
Not a fit: Patients with stable circadian rhythms and no related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating sleep disorders and other health issues linked to circadian rhythm disruptions.
How similar studies have performed: Previous research has shown promising results in understanding the connections between stress responses and circadian rhythms, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Cao, Ruifeng (Ray) — Rutgers Biomedical and Health Sciences
- Study coordinator: Cao, Ruifeng (Ray)
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.