How stress responses in lung cancer affect immune checkpoint regulation
Official title: Immune Checkpoint Regulation by the Integrated Stress Response Pathway in Lung Ca
Funded at Ut Southwestern Medical Center · NIH-11052554 · Data updated 2026-11-12
This study is looking at how lung cancer cells handle stress and how that helps them hide from the immune system, with the goal of finding better ways to improve treatments for lung cancer patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $80,224 |
| NIH project number | 5F32CA274982-03 |
| Project ID | NIH-11052554 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer (NSCLC) who may be receiving or considering PD-1/PD-L1 targeted therapies.
✕Less likely to help
Patients with other types of cancer or those who are not eligible for PD-1/PD-L1 therapies may not benefit from this research.
What this research studies
This research investigates how lung cancer cells respond to stress and how this affects their ability to evade the immune system. It focuses on the role of the integrated stress response (ISR) in regulating immune checkpoint proteins like PD-L1, which can suppress the body's anti-tumor immune response. By understanding these mechanisms, the research aims to identify new strategies to enhance the effectiveness of existing cancer therapies, particularly those targeting the PD-1/PD-L1 pathway. Patients may benefit from insights that could lead to improved treatment options for lung cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for lung cancer by overcoming resistance to current therapies.
How similar studies have gone: Previous research has shown promising results in targeting the PD-1/PD-L1 pathway, but the specific role of the ISR in this context is still being explored.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Thomas-Jardin, Shayna — Ut Southwestern Medical Center
- Study coordinator: Thomas-Jardin, Shayna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.