How stress responses in immune cells affect infections from Salmonella bacteria
Official title: Integrated Stress Response-mediated macrophage innate immunity during maladapted Salmonella enterica infection
Funded at University of Michigan at Ann Arbor · NIH-10994355 · Data updated 2026-11-12
This study is looking at how stress affects certain immune cells in our body that help fight off infections like typhoid fever, with the hope of finding new ways to boost our immune response against these types of bacteria.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,094 |
| NIH project number | 1F31AI186289-01 |
| Project ID | NIH-10994355 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of or have been diagnosed with typhoid fever or related Salmonella infections.
✕Less likely to help
Patients who do not have a history of Salmonella infections or are not at risk for typhoid fever may not benefit from this research.
What this research studies
This research investigates how stress responses in immune cells, specifically macrophages, influence the body's ability to fight off infections caused by Salmonella enterica, the bacteria responsible for typhoid fever. By studying how these immune cells adapt to stress during infection, the research aims to uncover mechanisms that could lead to new treatments. The approach involves using a model of infection to observe how the Integrated Stress Response (ISR) pathway is activated and how it affects immune function. The findings could provide insights into how to enhance immune responses against this global health threat.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve immune responses to Salmonella infections, potentially reducing the incidence and severity of typhoid fever.
How similar studies have gone: Previous research has shown that understanding stress responses in immune cells can lead to significant advancements in treating infectious diseases, suggesting that this approach has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Powers, Zachary Michael — University of Michigan at Ann Arbor
- Study coordinator: Powers, Zachary Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.