How stress hormones affect blood sugar levels
Sphingosine-1-phosphate Signaling and the Chronic Glucocorticoid Exposure Induced Glucose Homeostasis Disorder
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11145822
This project helps us understand how long-term exposure to stress hormones can lead to high blood sugar, a common issue in adult-onset diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11145822 on ClinicalTrials.gov |
What this research studies
When our bodies are exposed to stress hormones for a long time, like during chronic stress or certain medications, it can cause problems with how our bodies manage sugar. This research looks at how a specific molecule called sphingosine-1-phosphate (S1P) and its receptor (S1PR2) in the liver contribute to this problem by increasing sugar production. Scientists are studying how S1PR2 interacts with other genes to boost sugar production when stress hormones are high. By understanding these pathways, we hope to find new ways to help the liver better manage sugar levels.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying causes of adult-onset diabetes, especially when linked to long-term stress or glucocorticoid use.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target specific pathways in the liver to help manage high blood sugar caused by chronic stress or certain medications.
How similar studies have performed: While the role of glucocorticoids in metabolism is well-known, the specific involvement of sphingosine-1-phosphate signaling in this context is a novel area of investigation.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, JEN-CHYWAN — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: WANG, JEN-CHYWAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus