How stress during puberty affects breast health and cancer risk
Effects of chronic pubertal stressors on mammary gland biology and cancer risk
This study is looking at how stress during puberty might affect breast development and could lead to a higher risk of breast cancer later on, using a rat model to help understand the science behind it, and it aims to find ways to reduce these risks for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10890709 on NIH RePORTER |
What this research studies
This research investigates how chronic stress during puberty influences the development of the mammary gland and its potential link to increased breast cancer risk later in life. By using a rat model that mimics human breast cancer, the study aims to uncover the molecular mechanisms by which stress hormones affect mammary gland development. The research team, consisting of experts in breast cancer biology, endocrinology, and biopsychology, will also explore interventions that could mitigate these risks. Patients may benefit from insights gained about early life stressors and their long-term effects on breast health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals with a history of stress-related health issues or those concerned about breast cancer risk.
Not a fit: Patients who are not affected by stress or have no family history of breast cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for breast cancer prevention and care by identifying early life risk factors.
How similar studies have performed: Other research has shown promising results in understanding the impact of early life stress on cancer risk, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Brady, Matthew J — University of Chicago
- Study coordinator: Brady, Matthew J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.